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About Xanthohumol

Source Of Xanthohumol

Xanthohumol is a prenylated chalcone found naturally derived from the female flowers of Hop (Humulus lupulus) belongs to the family Cannabinaceae. Xanthohumol is formed in lupulin glands by a specialized branch of flavonoid biosynthesis that involves prenylation and O-methylation of the polyketide intermediate chalconaringenin.

Dandelion, Burdock root, Marigold, Horehound (the German word for horehound means "mountain hops"), Ground ivy and Heather were the prior source of Xanthohumol.

About Humulus lupulus

Common hop is a dioecious, perennial herbaceous climbing plant which sends up new shoots in early spring and dies back to the cold-hardy rhizome in autumn. It is native to the temperate Northern Hemisphere.

Isolation Of Xanthohumol

If xanthohumol should indeed turn out to be physiologically interesting for the pharmaceutical industry, its direct isolation from hops will have to be considered. Points of departure could be extraction methods using a suitable organic solvent (alcohols such as methanol, ethanol;esters such as

  Xanthohumol

Xanthohumol is a prenylated chalcone found naturally derived from the female flowers of Hop (Humulus lupulus) belongs to the family Cannabinaceae.  This prenylated flavonoid has been shown to be a potent bioactive compound.  Xanthohumol has been shown to have antiproliferative and cytotoxic effects in human cancer cell lines. 

Scientific classification

Kingdom:

Plantae

Division:

Magnoliophyta

Class:

Magnoliopsida

Order:

Rosales

Family:

Cannabaceae

Genus:

Humulus

Species:

H. lupulus

ethyl acetate; ketones such as acetone) after conventional CO2 extraction for the brewing industry to treat the xanthohumol-containing spent grains and obtain a xanthohumol-containing secondary extract. Another practicable method is the secondary processing of a xanthohumol-containing starting product such as an ethanol extract with a non-polar solvent (e.g. hexane or liquid or supercritical CO2) to obtain an soft resin extract and hop oil for the brewing industry and a xanthohumol-containing residual extract for the pharmaceutical industry.

Structure Of Xanthohumol

Xanthohumol is one of many flavonoids in hops and belongs to the chalcone group. Typically, polyphenols are concentrated in the leaves of the hop cone and have polar, hot water-soluble properties.

A Method For Preparing A Xanthohumol-Rich Hop Composition

A first solution containing hop substances and a first solvent, wherein the hop substances include 0.4-90% by weight xanthohumol and the first solvent includes up to 90% by volume water and at least 3% by volume a water miscible solvent; adjusting the salt concentration of the first solution to 0.05 M to 5.0 M and the pH value of the first solution to 9.5-13 to effect formation of a first precipitate; removing the first precipitate to obtain a second solution; adjusting the pH of the second solution to 3-9 to effect formation of a second precipitate; and collecting the second precipitate, wherein the second precipitate contains 40-95% by weight xanthohumol.

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